Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice

Ang II type 1 (AT1) receptors activate both conventional heterotrimeric G protein–dependent and unconventional G protein–independent mechanisms. We investigated how these different mechanisms activated by AT1 receptors affect growth and death of cardiac myocytes in vivo. Transgenic mice with cardiac...

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Hlavní autoři: Zhai, Peiyong, Yamamoto, Mitsutaka, Galeotti, Jonathan, Liu, Jing, Masurekar, Malthi, Thaisz, Jill, Irie, Keiichi, Holle, Eric, Yu, Xianzhong, Kupershmidt, Sabina, Roden, Dan M., Wagner, Thomas, Yatani, Atsuko, Vatner, Dorothy E., Vatner, Stephen F., Sadoshima, Junichi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2005
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265872/
https://ncbi.nlm.nih.gov/pubmed/16276415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25330
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