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Mutation of Y(179) on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K- and Akt-dependent manner
Phospholipase D2 (PLD2), one of the two mammalian members of the PLD family, has been implicated in cell proliferation, transformation, tumor progression and survival. However, as precise mechanistic details are still unknown, we investigated here if the PLD2 isoform would signal through the PI3K/AK...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276604/ https://ncbi.nlm.nih.gov/pubmed/18006275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.10.009 |
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