Characterization of the Gating Brake in the I-II Loop of Ca(v)3.2 T-type Ca(2+) Channels

Mutations in the I-II loop of Ca(v)3.2 channels were discovered in patients with childhood absence epilepsy. All of these mutations increased the surface expression of the channel, whereas some mutations, and in particular C456S, altered the biophysical properties of channels. Deletions around C456S...

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Hauptverfasser: Arias-Olguín, Imilla I., Vitko, Iuliia, Fortuna, Michal, Baumgart, Joel P., Sokolova, Svetlana, Shumilin, Igor A., Van Deusen, Amy, Soriano-García, Manuel, Gomora, Juan C., Perez-Reyes, Edward
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Membrane Transport, Structure, Function, and Biogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276388/
https://ncbi.nlm.nih.gov/pubmed/18218623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708761200
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