Orientation of the Calcium Channel β Relative to the α(1)2.2 Subunit Is Critical for Its Regulation of Channel Activity

BACKGROUND: The Ca(v)β subunits of high voltage-activated Ca(2+) channels control the trafficking and biophysical properties of the α(1) subunit. The Ca(v)β-α(1) interaction site has been mapped by crystallographic studies. Nevertheless, how this interaction leads to channel regulation has not been...

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Hlavní autoři: Vitko, Iuliia, Shcheglovitov, Aleksandr, Baumgart, Joel P., Arias-Olguín, Imilla I., Murbartián, Janet, Arias, Juan Manuel, Perez-Reyes, Edward
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570331/
https://ncbi.nlm.nih.gov/pubmed/18958281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003560
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