Structural Determinants of the High Affinity Extracellular Zinc Binding Site on Ca(v)3.2 T-type Calcium Channels

Ca(v)3.2 T-type channels contain a high affinity metal binding site for trace metals such as copper and zinc. This site is occupied at physiologically relevant concentrations of these metals, leading to decreased channel activity and pain transmission. A histidine at position 191 was recently identi...

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Bibliographic Details
Main Authors: Kang, Ho-Won, Vitko, Iuliia, Lee, Sang-Soo, Perez-Reyes, Edward, Lee, Jung-Ha
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823403/
https://ncbi.nlm.nih.gov/pubmed/19940152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067660
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