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Structural Determinants of the High Affinity Extracellular Zinc Binding Site on Ca(v)3.2 T-type Calcium Channels
Ca(v)3.2 T-type channels contain a high affinity metal binding site for trace metals such as copper and zinc. This site is occupied at physiologically relevant concentrations of these metals, leading to decreased channel activity and pain transmission. A histidine at position 191 was recently identi...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823403/ https://ncbi.nlm.nih.gov/pubmed/19940152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067660 |
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