Reducing Agents Sensitize C-Type Nociceptors by Relieving High-Affinity Zinc Inhibition of T-Type Calcium Channels

Recent studies have demonstrated an important role for T-type Ca(2+) channels (T-channels) in controlling the excitability of peripheral pain-sensing neurons (nociceptors). However, the molecular mechanisms underlying the functions of T-channels in nociceptors are poorly understood. Here, we demonst...

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Vydáno v:J Neurosci
Hlavní autoři: Nelson, Michael T., Woo, Jiwan, Kang, Ho-Won, Vitko, Iuliia, Barrett, Paula Q., Perez-Reyes, Edward, Lee, Jung-Ha, Shin, Hee-Sup, Todorovic, Slobodan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673068/
https://ncbi.nlm.nih.gov/pubmed/17670971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1800-07.2007
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