A Modeling Study of T-Type Ca(2+) Channel Gating and Modulation by L-Cysteine in Rat Nociceptors

L-cysteine (L-cys) increases the amplitude of T-type Ca(2+) currents in rat T-rich nociceptor-like dorsal root ganglia neurons. The modulation of T-type Ca(2+) channel gating by L-cys was studied by fitting Markov state models to whole-cell currents recorded from T-rich neurons. The best fitting mod...

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Главные авторы: Nelson, Michael T., Milescu, Lorin S., Todorovic, Slobodan M., Scroggs, Reese S.
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2010
Предметы:
Cellular Biophysics and Electrophysiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808491/
https://ncbi.nlm.nih.gov/pubmed/20338841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.10.007
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