Molecular Mechanisms of Lipoic Acid Modulation of T-Type Calcium Channels in Pain Pathway

α-Lipoic acid (1,2-dithiolane-3-pentanoic acid; lipoic acid) is an endogenous compound used to treat pain disorders in humans, but its mechanisms of analgesic action are not well understood. Here, we show that lipoic acid selectively inhibited native Ca(V)3.2 T-type calcium currents (T-currents) and...

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Detalhes bibliográficos
Main Authors: Lee, Woo Yong, Orestes, Peihan, Latham, Janelle, Naik, Ajit K., Nelson, Michael T., Vitko, Iuliia, Perez-Reyes, Edward, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073510/
https://ncbi.nlm.nih.gov/pubmed/19641113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5803-08.2009
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