Molecular Mechanisms of Lipoic Acid Modulation of T-Type Calcium Channels in Pain Pathway

α-Lipoic acid (1,2-dithiolane-3-pentanoic acid; lipoic acid) is an endogenous compound used to treat pain disorders in humans, but its mechanisms of analgesic action are not well understood. Here, we show that lipoic acid selectively inhibited native Ca(V)3.2 T-type calcium currents (T-currents) and...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Lee, Woo Yong, Orestes, Peihan, Latham, Janelle, Naik, Ajit K., Nelson, Michael T., Vitko, Iuliia, Perez-Reyes, Edward, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073510/
https://ncbi.nlm.nih.gov/pubmed/19641113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5803-08.2009
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker