Molecular Mechanisms of Lipoic Acid Modulation of T-Type Calcium Channels in Pain Pathway

α-Lipoic acid (1,2-dithiolane-3-pentanoic acid; lipoic acid) is an endogenous compound used to treat pain disorders in humans, but its mechanisms of analgesic action are not well understood. Here, we show that lipoic acid selectively inhibited native Ca(V)3.2 T-type calcium currents (T-currents) and...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Woo Yong, Orestes, Peihan, Latham, Janelle, Naik, Ajit K., Nelson, Michael T., Vitko, Iuliia, Perez-Reyes, Edward, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2009
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073510/
https://ncbi.nlm.nih.gov/pubmed/19641113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5803-08.2009
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