Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Ca(v)3.2 T-Type Calcium Channels

It has been established that Ca(V)3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of nociceptive sensory neurons (nociceptors) in response to hyperglycemia associated with diabetes, which in turn can be a basis for painful symptoms of p...

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Auteurs principaux: Orestes, Peihan, Osuru, Hari Prasad, McIntire, William E., Jacus, Megan O., Salajegheh, Reza, Jagodic, Miljen M., Choe, WonJoo, Lee, JeongHan, Lee, Sang-Soo, Rose, Kirstin E., Poiro, Nathan, DiGruccio, Michael R., Krishnan, Katiresan, Covey, Douglas F., Lee, Jung-Ha, Barrett, Paula Q., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2013
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806612/
https://ncbi.nlm.nih.gov/pubmed/23835327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0813
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