Glycosylation of Ca(V)3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes

Our previous studies implicated glycosylation of the Ca(V)3.2 isoform of T-type Ca(2+) channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms underlying the modulation of recombinant Ca(V)3.2 channel by de-glycosyl...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Joksimovic, Sonja Lj., Evans, J. Grayson, McIntire, William E., Orestes, Peihan, Barrett, Paula Q., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Cellular Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770106/
https://ncbi.nlm.nih.gov/pubmed/33384586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.605312
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