Selective inhibition of Ca(v)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates post-surgical pain

Pain-sensing sensory neurons of the dorsal root ganglion (DRG) can become sensitized (hyperexcitable) in response to surgically-induced peripheral tissue injury. However, the potential role and molecular mechanisms of nociceptive ion channel dysregulation in acute pain conditions such as those resul...

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Udgivet i:Sci Signal
Main Authors: Joksimovic, Sonja Lj., Joksimovic, Srdjan M., Tesic, Vesna, García-Caballero, Agustin, Feseha, Simon, Zamponi, Gerald W., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193449/
https://ncbi.nlm.nih.gov/pubmed/30154101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao4425
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