Free radical signalling underlies inhibition of Ca(V)3.2 T-type calcium channels by nitrous oxide in the pain pathway

Nitrous oxide (N(2)O, laughing gas) has been used as an anaesthetic and analgesic for almost two centuries, but its cellular targets remain unclear. Here, we present a molecular mechanism of nitrous oxide's selective inhibition of Ca(V)3.2 low-voltage-activated (T-type) calcium channels in pain...

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Detaylı Bibliyografya
Asıl Yazarlar: Orestes, Peihan, Bojadzic, Damir, Lee, JeongHan, Leach, Emily, Salajegheh, Reza, DiGruccio, Michael R, Nelson, Michael T, Todorovic, Slobodan M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2011
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039265/
https://ncbi.nlm.nih.gov/pubmed/21059758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.196220
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