Free radical signalling underlies inhibition of Ca(V)3.2 T-type calcium channels by nitrous oxide in the pain pathway

Nitrous oxide (N(2)O, laughing gas) has been used as an anaesthetic and analgesic for almost two centuries, but its cellular targets remain unclear. Here, we present a molecular mechanism of nitrous oxide's selective inhibition of Ca(V)3.2 low-voltage-activated (T-type) calcium channels in pain...

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Main Authors: Orestes, Peihan, Bojadzic, Damir, Lee, JeongHan, Leach, Emily, Salajegheh, Reza, DiGruccio, Michael R, Nelson, Michael T, Todorovic, Slobodan M
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2011
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039265/
https://ncbi.nlm.nih.gov/pubmed/21059758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.196220
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