Free radical signalling underlies inhibition of Ca(V)3.2 T-type calcium channels by nitrous oxide in the pain pathway

Nitrous oxide (N(2)O, laughing gas) has been used as an anaesthetic and analgesic for almost two centuries, but its cellular targets remain unclear. Here, we present a molecular mechanism of nitrous oxide's selective inhibition of Ca(V)3.2 low-voltage-activated (T-type) calcium channels in pain...

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Bibliographic Details
Main Authors: Orestes, Peihan, Bojadzic, Damir, Lee, JeongHan, Leach, Emily, Salajegheh, Reza, DiGruccio, Michael R, Nelson, Michael T, Todorovic, Slobodan M
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2011
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039265/
https://ncbi.nlm.nih.gov/pubmed/21059758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.196220
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