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Free radical signalling underlies inhibition of Ca(V)3.2 T-type calcium channels by nitrous oxide in the pain pathway
Nitrous oxide (N(2)O, laughing gas) has been used as an anaesthetic and analgesic for almost two centuries, but its cellular targets remain unclear. Here, we present a molecular mechanism of nitrous oxide's selective inhibition of Ca(V)3.2 low-voltage-activated (T-type) calcium channels in pain...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039265/ https://ncbi.nlm.nih.gov/pubmed/21059758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.196220 |
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