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Characterization of the Gating Brake in the I-II Loop of Ca(v)3.2 T-type Ca(2+) Channels
Mutations in the I-II loop of Ca(v)3.2 channels were discovered in patients with childhood absence epilepsy. All of these mutations increased the surface expression of the channel, whereas some mutations, and in particular C456S, altered the biophysical properties of channels. Deletions around C456S...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276388/ https://ncbi.nlm.nih.gov/pubmed/18218623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708761200 |
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