Characterization of the Gating Brake in the I-II Loop of Ca(v)3.2 T-type Ca(2+) Channels

Mutations in the I-II loop of Ca(v)3.2 channels were discovered in patients with childhood absence epilepsy. All of these mutations increased the surface expression of the channel, whereas some mutations, and in particular C456S, altered the biophysical properties of channels. Deletions around C456S...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Arias-Olguín, Imilla I., Vitko, Iuliia, Fortuna, Michal, Baumgart, Joel P., Sokolova, Svetlana, Shumilin, Igor A., Van Deusen, Amy, Soriano-García, Manuel, Gomora, Juan C., Perez-Reyes, Edward
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Membrane Transport, Structure, Function, and Biogenesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276388/
https://ncbi.nlm.nih.gov/pubmed/18218623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708761200
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