Characterization of the Gating Brake in the I-II Loop of Ca(v)3.2 T-type Ca(2+) Channels

Mutations in the I-II loop of Ca(v)3.2 channels were discovered in patients with childhood absence epilepsy. All of these mutations increased the surface expression of the channel, whereas some mutations, and in particular C456S, altered the biophysical properties of channels. Deletions around C456S...

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Main Authors: Arias-Olguín, Imilla I., Vitko, Iuliia, Fortuna, Michal, Baumgart, Joel P., Sokolova, Svetlana, Shumilin, Igor A., Van Deusen, Amy, Soriano-García, Manuel, Gomora, Juan C., Perez-Reyes, Edward
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276388/
https://ncbi.nlm.nih.gov/pubmed/18218623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708761200
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