2-Oxo-tetrahydro-1,8-naphthyridines as Selective Inhibitors of Malarial Protein Farnesyltransferase Inhibitors and as Antimalarials

A new class of 2-oxo-tetrahydro-1,8-naphthyridine-based protein farnesyltransferase inhibitors were synthesized and found to inhibit protein farnesyl transferase from the malaria parasite with potencies in the low nanomolar range. The compounds were much less potent on mammalian protein prenyltransf...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Olepu, Srinivas, Suryadevara, Praveen Kumar, Rivas, Kasey, Yokoyama, Kohei, Verlinde, Christophe L. M. J., Chakrabarti, Debopam, Van Voorhis, Wesley C., Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275803/
https://ncbi.nlm.nih.gov/pubmed/18077162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.104
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados