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Activation of NO Donors in Mitochondria: Peroxidase Metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by Cytochrome c Releases NO and Protects Cells Against Apoptosis
In mitochondrial apoptosis, the formation of cytochrome c-cardiolipin complex ([CL-cyt c]) with peroxidase properties is an early event in the cascade of reactions that leads to cell death. Herein, we report the synthesis of a new prodrug, (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP), which c...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275320/ https://ncbi.nlm.nih.gov/pubmed/18258194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.01.047 |
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