Activation of NO Donors in Mitochondria: Peroxidase Metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by Cytochrome c Releases NO and Protects Cells Against Apoptosis

In mitochondrial apoptosis, the formation of cytochrome c-cardiolipin complex ([CL-cyt c]) with peroxidase properties is an early event in the cascade of reactions that leads to cell death. Herein, we report the synthesis of a new prodrug, (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP), which c...

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Hauptverfasser: Stoyanovsky, Detcho A, Vlasova, Irina I, Belikova, Natalia A, Kapralov, Alexandr, Tyurin, Vladimir, Kagan, Valerian E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275320/
https://ncbi.nlm.nih.gov/pubmed/18258194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.01.047
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