A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation induced death

The risk of radionuclide release in terrorist acts or exposure of healthy tissue during radiotherapy demand potent radioprotectants/radiomitigators. Ionizing radiation induces cell death by initiating the selective peroxidation of cardiolipin in mitochondria by the peroxidase activity of its complex...

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Autors principals: Atkinson, Jeffrey, Kapralov, Alexandr A., Yanamala, Naveena, Tyurina, Yulia Y., Amoscato, Andrew A., Pearce, Linda, Peterson, Jim, Huang, Zhentai, Jiang, Jianfei, Samhan-Arias, Alejandro K., Maeda, Akihiro, Feng, Weihong, Wasserloos, Karla, Belikova, Natalia A., Tyurin, Vladimir A., Wang, Hong, Fletcher, Jackie, Wang, Yongsheng, Vlasova, Irina I., Klein-Seetharaman, Judith, Stoyanovsky, Detcho A., Bayîr, Hülya, Pitt, Bruce R., Epperly, Michael W., Greenberger, Joel S., Kagan, Valerian E.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557495/
https://ncbi.nlm.nih.gov/pubmed/21988913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1499
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