A Manganese–Porphyrin Complex Decomposes H(2)O(2), Inhibits Apoptosis, and Acts as a Radiation Mitigator in Vivo

[Image: see text] Ionizing radiation triggers mitochondrial overproduction of H(2)O(2) with concomitant induction of intrinsic apoptosis, whereby clearance of H(2)O(2) upon overexpression of mitochondrial catalase increases radioresistance in vitro and in vivo. As an alternative to gene therapy, we...

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Auteurs principaux: Stoyanovsky, Detcho A., Huang, Zhentai, Jiang, Jianfei, Belikova, Natalia A., Tyurin, Vladimir, Epperly, Michael W., Greenberger, Joel S., Bayir, Hülya, Kagan, Valerian E.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2011
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254103/
https://ncbi.nlm.nih.gov/pubmed/22247787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200142x
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