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A Manganese–Porphyrin Complex Decomposes H(2)O(2), Inhibits Apoptosis, and Acts as a Radiation Mitigator in Vivo
[Image: see text] Ionizing radiation triggers mitochondrial overproduction of H(2)O(2) with concomitant induction of intrinsic apoptosis, whereby clearance of H(2)O(2) upon overexpression of mitochondrial catalase increases radioresistance in vitro and in vivo. As an alternative to gene therapy, we...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical Society
2011
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3254103/ https://ncbi.nlm.nih.gov/pubmed/22247787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200142x |
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