A Manganese–Porphyrin Complex Decomposes H(2)O(2), Inhibits Apoptosis, and Acts as a Radiation Mitigator in Vivo

[Image: see text] Ionizing radiation triggers mitochondrial overproduction of H(2)O(2) with concomitant induction of intrinsic apoptosis, whereby clearance of H(2)O(2) upon overexpression of mitochondrial catalase increases radioresistance in vitro and in vivo. As an alternative to gene therapy, we...

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Detalhes bibliográficos
Main Authors: Stoyanovsky, Detcho A., Huang, Zhentai, Jiang, Jianfei, Belikova, Natalia A., Tyurin, Vladimir, Epperly, Michael W., Greenberger, Joel S., Bayir, Hülya, Kagan, Valerian E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254103/
https://ncbi.nlm.nih.gov/pubmed/22247787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200142x
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