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Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator
[Image: see text] Ionizing radiation (IR) triggers mitochondrial overproduction of H(2)O(2) and accumulation of lipid hydroperoxides leading to the induction of apoptotic and necroptotic cell death pathways. Given the high catalytic efficiency of the seleno-enzyme glutathione peroxidase (Gpx) toward...
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| Veröffentlicht in: | ACS Med Chem Lett |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4266336/ https://ncbi.nlm.nih.gov/pubmed/25530831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5003635 |
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