Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

[Image: see text] Ionizing radiation (IR) triggers mitochondrial overproduction of H(2)O(2) and accumulation of lipid hydroperoxides leading to the induction of apoptotic and necroptotic cell death pathways. Given the high catalytic efficiency of the seleno-enzyme glutathione peroxidase (Gpx) toward...

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Publicado en:ACS Med Chem Lett
Autores principales: Stoyanovsky, Detcho A., Jiang, Jianfei, Murphy, Michael P., Epperly, Michael, Zhang, Xiaolan, Li, Song, Greenberger, Joel, Kagan, Valerian, Bayır, Hülya
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266336/
https://ncbi.nlm.nih.gov/pubmed/25530831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5003635
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