Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO* and protects mouse embryonic cells against irradiation-induced apoptosis

Generation of reactive oxygen species by damaged respiratory chain followed by the formation of cytochrome c-cardiolipin complex with peroxidase activity are early events in apoptosis. By quenching the peroxidase activity of cytochrome c-cardiolipin complexes in mitochondria, nitric oxide can exert...

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Hlavní autoři: Belikova, Natalia A, Jiang, Jianfei, Stoyanovsky, Detcho A, Glumac, Ashley, Bayir, Hülya, Greenberger, Joel S, Kagan, Valerian E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696693/
https://ncbi.nlm.nih.gov/pubmed/19427865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.04.050
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