The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis

All UDP-glucuronosyltransferase enzymes (UGTs) share a common cofactor, UDP-glucuronic acid (UDP-GlcUA). The binding site for UDP-GlcUA is localized to the C-terminal domain of UGTs on the basis of amino acid sequence homology analysis and crystal structures of glycosyltransferases, including the C-...

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Main Authors: Xiong, Yan, Patana, Anne-Sisko, Miley, Michael J., Zielinska, Agnieszka K., Bratton, Stacie M., Miller, Grover P., Goldman, Adrian, Finel, Moshe, Redinbo, Matt R., Radominska-Pandya, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275115/
https://ncbi.nlm.nih.gov/pubmed/18048489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.107.016469
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