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Proteasomal inhibition stabilizes topoisomerase IIα protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide)

Multiple myeloma (MM) is an incurable malignancy of plasma cells. Although multiple myeloma patients often respond to initial therapy, the majority of patients will relapse with disease that is refractory to further drug treatment. Thus, new therapeutic strategies are needed. One common mechanism of...

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Detalhes bibliográficos
Main Authors: Congdon, Lauren M., Pourpak, Alan, Escalante, Aluvia M., Dorr, Robert T., Landowski, Terry H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271051/
https://ncbi.nlm.nih.gov/pubmed/18062937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.10.026
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