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Phenanthriplatin Acts as a Covalent Topoisomerase II Poison

Drugs capable of trapping topoisomerase II (Top2), an essential enzyme that cleaves double-stranded DNA in order to remove naturally occurring knots and tangles, can serve as potent anticancer agents. The monofunctional platinum anticancer agent phenanthriplatin, cis-[Pt(NH(3))(2)(phenanthridine)Cl]...

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Publicat a:ACS Chem Biol
Autors principals: Riddell, Imogen A., Park, Ga Young, Agama, Keli, Pommier, Yves, Lippard, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248983/
https://ncbi.nlm.nih.gov/pubmed/27648475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00565
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