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Phenanthriplatin Acts as a Covalent Topoisomerase II Poison
Drugs capable of trapping topoisomerase II (Top2), an essential enzyme that cleaves double-stranded DNA in order to remove naturally occurring knots and tangles, can serve as potent anticancer agents. The monofunctional platinum anticancer agent phenanthriplatin, cis-[Pt(NH(3))(2)(phenanthridine)Cl]...
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| izdano v: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5248983/ https://ncbi.nlm.nih.gov/pubmed/27648475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00565 |
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