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Nucleotide Binding Preference of the Monofunctional Platinum Anticancer Agent Phenanthriplatin
The monofunctional platinum anticancer agent phenanthriplatin generates covalent adducts with the purine bases guanine and adenine. Preferential nucleotide binding was investigated using a polymerase stop assay and linear DNA amplification with a 163-base pair DNA double helix. Like cisplatin, phena...
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| Publicado no: | Chemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4884344/ https://ncbi.nlm.nih.gov/pubmed/27111128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201600236 |
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