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Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis

Transcription inhibition by platinum anticancer drugs is an important component of their mechanism of action. Phenanthriplatin, a cisplatin derivative containing phenanthridine in place of one of the chloride ligands, forms highly potent monofunctional adducts on DNA having a structure and spectrum...

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Detaylı Bibliyografya
Asıl Yazarlar: Kellinger, Matthew W., Park, Ga Young, Chong, Jenny, Lippard, Stephen J., Wang, Dong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791135/
https://ncbi.nlm.nih.gov/pubmed/23927577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja405475y
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