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Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II
The reaction mechanism of DNA topoisomerase II (TOP2) involves a covalent double-strand break intermediate in which the enzyme is coupled to DNA via a 5′-phosphotyrosyl bond. This normally transient enzyme-bridged break is stabilised by drugs such as mitoxantrone, mAMSA, etoposide, doxorubicin, epir...
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| Publicado no: | Biochem Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5071433/ https://ncbi.nlm.nih.gov/pubmed/26794000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.12.015 |
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