MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires removal of topoisomerase II. To analyse removal of...

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Detalhes bibliográficos
Main Authors: Lee, Ka Cheong, Padget, Kay, Curtis, Hannah, Cowell, Ian G., Moiani, Davide, Sondka, Zbyslaw, Morris, Nicholas J., Jackson, Graham H., Cockell, Simon J., Tainer, John A., Austin, Caroline A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507232/
https://ncbi.nlm.nih.gov/pubmed/23213480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20121834
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