Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

Topoisomerase poisons such as the epipodophyllotoxin etoposide are widely used effective cytotoxic anticancer agents. However, they are associated with the development of therapy-related acute myeloid leukemias (t-AMLs), which display characteristic balanced chromosome translocations, most often inv...

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Main Authors: Cowell, Ian G., Sondka, Zbyslaw, Smith, Kayleigh, Lee, Ka Cheong, Manville, Catriona M., Sidorczuk-Lesthuruge, Malgorzata, Rance, Holly Ashlene, Padget, Kay, Jackson, Graham Hunter, Adachi, Noritaka, Austin, Caroline A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384169/
https://ncbi.nlm.nih.gov/pubmed/22615413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204406109
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