Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

Human helicase-like transcription factor (HLTF) is frequently inactivated in colorectal and gastric cancers. Here, we show that HLTF is a functional homologue of yeast Rad5 that promotes error-free replication through DNA lesions. HLTF and Rad5 share the same unique structural features, including a...

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Detalhes bibliográficos
Main Authors: Unk, Ildiko, Hajdú, Ildikó, Fátyol, Károly, Hurwitz, Jerard, Yoon, Jung-Hoon, Prakash, Louise, Prakash, Satya, Haracska, Lajos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268824/
https://ncbi.nlm.nih.gov/pubmed/18316726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800563105
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