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Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination
Human helicase-like transcription factor (HLTF) is frequently inactivated in colorectal and gastric cancers. Here, we show that HLTF is a functional homologue of yeast Rad5 that promotes error-free replication through DNA lesions. HLTF and Rad5 share the same unique structural features, including a...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268824/ https://ncbi.nlm.nih.gov/pubmed/18316726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800563105 |
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