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The microbial mimic poly IC induces durable and protective CD4(+) T cell immunity together with a dendritic cell targeted vaccine

CD4(+) Th1 type immunity is implicated in resistance to global infectious diseases. To improve the efficacy of T cell immunity induced by human immunodeficiency virus (HIV) vaccines, we are developing a protein-based approach that directly harnesses the function of dendritic cells (DCs) in intact ly...

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Hlavní autoři: Trumpfheller, Christine, Caskey, Marina, Nchinda, Godwin, Longhi, Maria Paula, Mizenina, Olga, Huang, Yaoxing, Schlesinger, Sarah J., Colonna, Marco, Steinman, Ralph M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268178/
https://ncbi.nlm.nih.gov/pubmed/18256187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711976105
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