Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

Type I interferons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adaptive immune responses. On dendritic cells (DCs), IFNs facilitate their activation and contribute to CD8(+) and CD4(+) T cell priming. However, the precise molecular mechanism by which I...

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Hauptverfasser: Pantel, Austin, Teixeira, Angela, Haddad, Elias, Wood, Elizabeth G., Steinman, Ralph M., Longhi, M. Paula
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883643/
https://ncbi.nlm.nih.gov/pubmed/24409099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001759
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