A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T cell immunity in vivo

Protein-based vaccines offer safety and cost advantages but require adjuvants to induce immunity. Glucopyranosyl Lipid A (GLA) is a new synthetic non-toxic analogue of lipopolysaccharide. In mice, in comparison to non-formulated LPS and another analog Monophosphoryl Lipid A, formulated GLA induced h...

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Detalhes bibliográficos
Main Authors: Pantel, Austin, Cheong, Cheolho, Dandamudi, Durga, Shrestha, Elina, Mehandru, Saurabh, Brane, Luke, Ruane, Darren, Teixeira, Angela, Bozzacco, Leonia, Steinman, Ralph M, Longhi, Paula M
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517108/
https://ncbi.nlm.nih.gov/pubmed/22002164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141855
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