Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti–human DEC205 monoclonal antibody

Protein vaccines for T-cell immunity are not being prioritized because of poor immunogenicity. To overcome this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibodies (mAbs) to DC receptors. To extend the concept to humans, we immunized human immunoglobuli...

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Библиографические подробности
Главные авторы: Cheong, Cheolho, Choi, Jae-Hoon, Vitale, Laura, He, Li-Zhen, Trumpfheller, Christine, Bozzacco, Leonia, Do, Yoonkyung, Nchinda, Godwin, Park, Sung Ho, Dandamudi, Durga Bhavani, Shrestha, Elina, Pack, Maggi, Lee, Han-Woong, Keler, Tibor, Steinman, Ralph M., Park, Chae Gyu
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Immunobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981538/
https://ncbi.nlm.nih.gov/pubmed/20668230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-288068
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