Dendritic cells require a systemic type I interferon response to mature and induce CD4(+) Th1 immunity with poly IC as adjuvant

Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)–targeted HIV gag protein vaccine in mice. To identify mechanisms for adjuvant action in the intac...

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Detalhes bibliográficos
Main Authors: Longhi, M. Paula, Trumpfheller, Christine, Idoyaga, Juliana, Caskey, Marina, Matos, Ines, Kluger, Courtney, Salazar, Andres M., Colonna, Marco, Steinman, Ralph M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715098/
https://ncbi.nlm.nih.gov/pubmed/19564349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090247
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