RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1

Platelet-endothelial cell adhesion molecule-1 (PECAM-1), a transmembrane glycoprotein involved in leukocyte transmigration, represents a good target for endothelial drug delivery (eg, using antibody-directed nanocarriers, anti-PECAM/NCs). Although endothelial cells do not internalize PECAM antibodie...

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Main Authors: Garnacho, Carmen, Shuvaev, Vladimir, Thomas, Anu, McKenna, Lindsay, Sun, Jing, Koval, Michael, Albelda, Steven, Muzykantov, Vladimir, Muro, Silvia
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265450/
https://ncbi.nlm.nih.gov/pubmed/18182571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-098657
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