Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Means to prevent thrombus extension and local recurrence remain suboptimal, in part because of the limited effectiveness of existing thrombolytics. In theory, plasminogen activators could be used for this purpose if they could be anchored to the vascular lumen by targeting stably expressed, noninter...

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Главные авторы: Ding, Bi-Sen, Gottstein, Claudia, Grunow, Andrea, Kuo, Alice, Ganguly, Kumkum, Albelda, Steven M., Cines, Douglas B., Muzykantov, Vladimir R.
Формат: Artigo
Язык:Inglês
Опубликовано: © 2005 by The American Society of Hematology 2005
Предметы:
Hemostasis, Thrombosis, and Vascular Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895234/
https://ncbi.nlm.nih.gov/pubmed/16144802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2002
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