Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Means to prevent thrombus extension and local recurrence remain suboptimal, in part because of the limited effectiveness of existing thrombolytics. In theory, plasminogen activators could be used for this purpose if they could be anchored to the vascular lumen by targeting stably expressed, noninter...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ding, Bi-Sen, Gottstein, Claudia, Grunow, Andrea, Kuo, Alice, Ganguly, Kumkum, Albelda, Steven M., Cines, Douglas B., Muzykantov, Vladimir R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: © 2005 by The American Society of Hematology 2005
Θέματα:
Hemostasis, Thrombosis, and Vascular Biology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895234/
https://ncbi.nlm.nih.gov/pubmed/16144802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2002
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