Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Means to prevent thrombus extension and local recurrence remain suboptimal, in part because of the limited effectiveness of existing thrombolytics. In theory, plasminogen activators could be used for this purpose if they could be anchored to the vascular lumen by targeting stably expressed, noninter...

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Bibliografiska uppgifter
Huvudupphovsmän: Ding, Bi-Sen, Gottstein, Claudia, Grunow, Andrea, Kuo, Alice, Ganguly, Kumkum, Albelda, Steven M., Cines, Douglas B., Muzykantov, Vladimir R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: © 2005 by The American Society of Hematology 2005
Ämnen:
Hemostasis, Thrombosis, and Vascular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895234/
https://ncbi.nlm.nih.gov/pubmed/16144802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2002
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