Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature

A recombinant prodrug, single-chain urokinase-type plasminogen activator (scuPA) fused to an anti–PECAM-1 antibody single-chain variable fragment (anti–PECAM scFv/scuPA) targets endothelium and augments thrombolysis in the pulmonary vasculature.(1) To avoid premature activation and inactivation and...

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Detalles Bibliográficos
Main Authors: Ding, Bi-Sen, Hong, Nankang, Murciano, Juan-Carlos, Ganguly, Kumkum, Gottstein, Claudia, Christofidou-Solomidou, Melpo, Albelda, Steven M., Fisher, Aron B., Cines, Douglas B., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234048/
https://ncbi.nlm.nih.gov/pubmed/18045968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-103002
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