A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. In particular, transient increased expression of Sirt1 is sufficient to stimulate basal rates of autophagy. In addition, we show that Sirt1(−/−) mouse embryonic fibroblasts do not fully activate autophagy u...

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Bibliographic Details
Main Authors: Lee, In Hye, Cao, Liu, Mostoslavsky, Raul, Lombard, David B., Liu, Jie, Bruns, Nicholas E., Tsokos, Maria, Alt, Frederick W., Finkel, Toren
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265142/
https://ncbi.nlm.nih.gov/pubmed/18296641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712145105
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