CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1

Macroautophagy/autophagy is an important intracellular mechanism for the maintenance of cellular homeostasis. Here we show that the CERKL (ceramide kinase like) gene, a retinal degeneration (RD) pathogenic gene, plays a critical role in regulating autophagy by stabilizing SIRT1. In vitro and in vivo...

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Bibliographic Details
Published in:Autophagy
Main Authors: Hu, Xuebin, Lu, Zhaojing, Yu, Shanshan, Reilly, James, Liu, Fei, Jia, Danna, Qin, Yayun, Han, Shanshan, Liu, Xiliang, Qu, Zhen, Lv, Yuexia, Li, Jingzhen, Huang, Yuwen, Jiang, Tao, Jia, Haibo, Wang, Qing, Liu, Jingyu, Shu, Xinhua, Tang, Zhaohui, Liu, Mugen
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351130/
https://ncbi.nlm.nih.gov/pubmed/30205735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1520548
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