Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing

Dysfunction of splicing factors often result in abnormal cell differentiation and apoptosis, especially in neural tissues. Mutations in pre-mRNAs processing factor 31 (PRPF31) cause autosomal dominant retinitis pigmentosa, a progressive retinal degeneration disease. The transcriptome-wide splicing e...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Li, Jingzhen, Liu, Fei, Lv, Yuexia, Sun, Kui, Zhao, Yuntong, Reilly, Jamas, Zhang, Yangjun, Tu, Jiayi, Yu, Shanshan, Liu, Xiliang, Qin, Yayun, Huang, Yuwen, Gao, Pan, Jia, Danna, Chen, Xiang, Han, Yunqiao, Shu, Xinhua, Luo, Daji, Tang, Zhaohui, Liu, Mugen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913766/
https://ncbi.nlm.nih.gov/pubmed/33476374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab003
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