Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing

Dysfunction of splicing factors often result in abnormal cell differentiation and apoptosis, especially in neural tissues. Mutations in pre-mRNAs processing factor 31 (PRPF31) cause autosomal dominant retinitis pigmentosa, a progressive retinal degeneration disease. The transcriptome-wide splicing e...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Li, Jingzhen, Liu, Fei, Lv, Yuexia, Sun, Kui, Zhao, Yuntong, Reilly, Jamas, Zhang, Yangjun, Tu, Jiayi, Yu, Shanshan, Liu, Xiliang, Qin, Yayun, Huang, Yuwen, Gao, Pan, Jia, Danna, Chen, Xiang, Han, Yunqiao, Shu, Xinhua, Luo, Daji, Tang, Zhaohui, Liu, Mugen
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913766/
https://ncbi.nlm.nih.gov/pubmed/33476374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab003
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